Mods will work on any version of the game, downloaded or hard copy. The trouble comes from Windows 10 itself, which had an update that makes the game crash on penalties and other particular situations. The two ways to fix it.
The simplest way is to use
Calhoupe's Madden Scripts. All you have to do is download his set of scripts, which come with other options to use more modern rules. You can skip those other features if you want, main point is to run the scripts along with the game. If you do that, the crashing will stop.
The other way to fix it is to set up a virtual machine, with either an older version of Windows 10 (before the Fall Creators patch) or an older version of Windows altogether, like Windows 7.